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Probing the Interaction of Arg9Cys Mutated Phospholamban with Phospholipid Bilayers by Solid-state NMR Spectroscopy

Phospholamban (PLB) is a 52 amino acid integral membrane protein that interacts with the sarcoplasmic reticulum Ca(2+) ATPase (SERCA) and helps to regulate Ca(2+) flow. PLB inhibits SERCA impairing Ca(2+) translocation. The inhibition can be relieved upon phosphorylation of PLB. The Arg9 to Cys (R9C...

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Autors principals: Yu, Xueting, Lorigan, Gary A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799966/
https://ncbi.nlm.nih.gov/pubmed/23850636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2013.07.003
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