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Structural Modulation of Human Amylin Protofilaments by Naturally Occurring Mutations
Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37-amino-acid peptide, co-secreted with insulin, and widely found in fibril form in type-2 diabetes patients. By using allatom molecular dynamics simulations, we study hIAPP fibril segments (i.e., fibrillar oligomers) formed with se...
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| Publié dans: | J Phys Chem B |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6428083/ https://ncbi.nlm.nih.gov/pubmed/29406755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b12083 |
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