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TAD fusion score: discovery and ranking the contribution of deletions to genome structure

Deletions that fuse two adjacent topologically associating domains (TADs) can cause severe developmental disorders. We provide a formal method to quantify deletions based on their potential disruption of the three-dimensional genome structure, denoted as the TAD fusion score. Furthermore, we show th...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Huynh, Linh, Hormozdiari, Fereydoun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6427865/
https://ncbi.nlm.nih.gov/pubmed/30898144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1666-7
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