CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors

mPGES-1 is a terminal rate-limiting enzyme responsible for inflammation-induced PGE2 production. The inhibition of mPGES-1 has been considered as a safe and effective target for the treatment of inflammation and cancer. However, a specific, efficient, and simple method for high-throughput screening...

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Bibliographic Details
Published in:J Enzyme Inhib Med Chem
Main Authors: Chen, Zhanfei, Cai, Xiaoling, Li, Man, Yan, LinLin, Wu, Luxi, Wang, Xiaoqian, Tang, Nanhong
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6427568/
https://ncbi.nlm.nih.gov/pubmed/30879343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1587416
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