Implications of Individual QT/RR Profiles—Part 2: Zero QTc/RR Correlations Do Not Prove QTc Correction Accuracy in Studies of QTc Changes

INTRODUCTION: In studies of drug-induced corrected QT (QTc) changes, fixed universal heart rate (HR) corrections (e.g., the Fridericia correction) are potentially misleading when assessing the effects of drugs that change HR. When data-specific corrections are designed, tests of their validity are n...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Drug Saf
Päätekijät: Malik, Marek, Garnett, Christine, Hnatkova, Katerina, Vicente, Jose, Johannesen, Lars, Stockbridge, Norman
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer International Publishing 2018
Aiheet:
Original Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426831/
https://ncbi.nlm.nih.gov/pubmed/30255348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-018-0735-2
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