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Importance of QT/RR hysteresis correction in studies of drug-induced QTc interval changes

QT/RR hysteresis and QT/RR adaptation are interlinked but separate physiological processes signifying how quickly and how much QT interval changes when heart rate changes, respectively. While QT interval duration is, as a rule, corrected for heart rate in terms of the QT/RR adaptation, the correctio...

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Detalhes bibliográficos
Publicado no:J Pharmacokinet Pharmacodyn
Main Authors: Malik, Marek, Garnett, Christine, Hnatkova, Katerina, Johannesen, Lars, Vicente, Jose, Stockbridge, Norman
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953973/
https://ncbi.nlm.nih.gov/pubmed/29651591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-018-9587-8
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