Diarylureas Containing 5-Membered Heterocycles as CB(1) Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation

Allosteric modulators have attracted significant interest as an alternate strategy to modulate CB(1) receptor signaling for therapeutic benefits that may avoid the adverse effects associated with orthosteric ligands. Here we extended our previous structure-activity relationship studies on the diaryl...

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Udgivet i:ACS Chem Neurosci
Main Authors: Nguyen, Thuy, Gamage, Thomas F., Decker, Ann M., German, Nadezhda, Langston, Tiffany L., Farquhar, Charlotte E., Kenakin, Terry P., Wiley, Jenny L., Thomas, Brian F., Zhang, Yanan
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426682/
https://ncbi.nlm.nih.gov/pubmed/30188693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00396
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