The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB(1) receptor allosteric modulators

While allosteric modulators of the cannabinoid type-1 receptor (CB(1)) continue to be developed and characterized, the gap between the in vitro and in vivo data is widening, raising questions regarding translatability of their effects and biological relevance. Among the CB(1) allosteric modulators,...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Gamage, Thomas F., Farquhar, Charlotte E., Lefever, Timothy W., Thomas, Brian F., Nguyen, Thuy, Zhang, Yanan, Wiley, Jenny L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771238/
https://ncbi.nlm.nih.gov/pubmed/28803965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.08.008
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