Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

Verticipyrone has recently been isolated from the culture broth of Verticillium sp. and shown to inhibit NADH fumarate reductase, as well as NADH oxidoreductase (complex I) of the mitochondrial electron transport chain. In order to assess the structural elements in verticipyrone essential for comple...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Leiris, Simon J., Khdour, Omar M., Segerman, Zachary J., Tsosie, Krystal S., Chapuis, Jean-Charles, Hecht, Sidney M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426446/
https://ncbi.nlm.nih.gov/pubmed/20456960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.03.070
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