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Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

Stress granules (SGs) are non-membrane-bound RNA-protein granules that assemble through phase separation in response to cellular stress. Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotempora...

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Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Zhang, Peipei, Fan, Baochang, Yang, Peiguo, Temirov, Jamshid, Messing, James, Kim, Hong Joo, Taylor, J Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426440/
https://ncbi.nlm.nih.gov/pubmed/30893049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39578
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