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Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology
Stress granules (SGs) are non-membrane-bound RNA-protein granules that assemble through phase separation in response to cellular stress. Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotempora...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426440/ https://ncbi.nlm.nih.gov/pubmed/30893049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39578 |
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