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DRB4 has a distinct motif and presents a proinsulin epitope that is recognized in subjects with type 1 diabetes
DRB4*01:01 (DRB4) is a secondary HLA-DR product which is part of the high risk DR4/DQ8 haplotype that is associated with type 1 diabetes (T1D). DRB4 shares considerable homology with HLA-DR4 alleles that predispose to autoimmunity, including DRB1*04:01 and DRB1*04:04. However the DRB4 protein sequen...
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| Publicado en: | J Immunol |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426329/ https://ncbi.nlm.nih.gov/pubmed/30455401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800723 |
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