DRB4 has a distinct motif and presents a proinsulin epitope that is recognized in subjects with type 1 diabetes

DRB4*01:01 (DRB4) is a secondary HLA-DR product which is part of the high risk DR4/DQ8 haplotype that is associated with type 1 diabetes (T1D). DRB4 shares considerable homology with HLA-DR4 alleles that predispose to autoimmunity, including DRB1*04:01 and DRB1*04:04. However the DRB4 protein sequen...

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發表在:J Immunol
Main Authors: James, Eddie A., Gillette, Laurel, Durinovic-Bello, Ivana, Speake, Cate, Bondinas, George P., Moustakas, Antonis K., Greenbaum, Carla J., Papadopoulos, George K., Kwok, William W.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426329/
https://ncbi.nlm.nih.gov/pubmed/30455401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800723
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