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Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
Insulin is a major target of the autoimmune response associated with destruction of pancreatic β cells in type 1 diabetes. A peptide that spans the junction of the insulin B chain and the connecting (C) peptide in proinsulin has been reported to stimulate T cells from humans at risk for type 1 diabe...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC154446/ https://ncbi.nlm.nih.gov/pubmed/12727928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317166 |
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