Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

Insulin is a major target of the autoimmune response associated with destruction of pancreatic β cells in type 1 diabetes. A peptide that spans the junction of the insulin B chain and the connecting (C) peptide in proinsulin has been reported to stimulate T cells from humans at risk for type 1 diabe...

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Bibliographic Details
Main Authors: Martinez, Nathan R., Augstein, Petra, Moustakas, Antonis K., Papadopoulos, George K., Gregori, Silvia, Adorini, Luciano, Jackson, David C., Harrison, Leonard C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC154446/
https://ncbi.nlm.nih.gov/pubmed/12727928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317166
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