載入...
Structure-guided design of a high-affinity ligand for a riboswitch
We have designed structure-based ligands for the guanidine-II riboswitch that bind with enhanced affinity, exploiting the twin binding sites created by loop–loop interaction. We synthesized diguanidine species, comprising two guanidino groups covalently connected by C(n) linkers where n = 4 or 5. Ca...
Na minha lista:
| 發表在: | RNA |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2019
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426286/ https://ncbi.nlm.nih.gov/pubmed/30609994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.069567.118 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|