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Structure-guided design of a high-affinity ligand for a riboswitch
We have designed structure-based ligands for the guanidine-II riboswitch that bind with enhanced affinity, exploiting the twin binding sites created by loop–loop interaction. We synthesized diguanidine species, comprising two guanidino groups covalently connected by C(n) linkers where n = 4 or 5. Ca...
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| Udgivet i: | RNA |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426286/ https://ncbi.nlm.nih.gov/pubmed/30609994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.069567.118 |
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