Human B Cells Engage the NCK/PI3K/RAC1 Axis to Internalize Large Particles via the IgM-BCR

Growing evidence indicate that large antigen-containing particles induce potent T cell-dependent high-affinity antibody responses. These responses require large particle internalization after recognition by the B cell receptor (BCR) on B cells. However, the molecular mechanisms governing BCR-mediate...

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發表在:Front Immunol
Main Authors: Verstegen, Niels J. M., Unger, Peter-Paul A., Walker, Julia Z., Nicolet, Benoit P., Jorritsma, Tineke, van Rijssel, Jos, Spaapen, Robbert M., de Wit, Jelle, van Buul, Jaap D., ten Brinke, Anja, van Ham, S. Marieke
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425997/
https://ncbi.nlm.nih.gov/pubmed/30930895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00415
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