Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL.

The Plant Homeodomain 6 gene (PHF6) is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL), however its specific functional role in leukemia development remains to be established. Here we show that loss of PHF6 is an early mutational event in leukemia transformation. Mechanistica...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Wendorff, Agnieszka A., Quinn, S. Aidan, Rashkovan, Marissa, Madubata, Chioma J., Ambesi-Impiombato, Alberto, Litzow, Mark R., Tallman, Martin S., Paietta, Elisabeth, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Loh, Mignon L., Rabadan, Raul, Van Vlierberghe, Pieter, Ferrando, Adolfo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425751/
https://ncbi.nlm.nih.gov/pubmed/30567843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1005
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