Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL.

The Plant Homeodomain 6 gene (PHF6) is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL), however its specific functional role in leukemia development remains to be established. Here we show that loss of PHF6 is an early mutational event in leukemia transformation. Mechanistica...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cancer Discov
Autores principales: Wendorff, Agnieszka A., Quinn, S. Aidan, Rashkovan, Marissa, Madubata, Chioma J., Ambesi-Impiombato, Alberto, Litzow, Mark R., Tallman, Martin S., Paietta, Elisabeth, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Loh, Mignon L., Rabadan, Raul, Van Vlierberghe, Pieter, Ferrando, Adolfo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425751/
https://ncbi.nlm.nih.gov/pubmed/30567843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1005
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares