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Soluble Fc-disabled HVEM augments activation and cytotoxicity of NK cells by promoting crosstalk between NK cells and monocytes.
CD160 is highly expressed by natural killer (NK) cells and associated with cytolytic effector activity. Herpes virus entry mediator (HVEM) activates NK cells for cytokine production and cytolytic function via CD160. Fc-fusions are a well-established class of therapeutics, where the Fc-domain provide...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6424646/ https://ncbi.nlm.nih.gov/pubmed/30770415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801449 |
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