Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes

PURPOSE: Over 95% of human anal cancers are etiologically associated with high-risk HPVs, with HPV type 16 (HPV16) the genotype most commonly found. Activating mutations in the catalytic subunit of Phosphatidylinositol (3,4,5)-trisphosphate kinase (PI3K), encoded by the Pik3ca gene, are detected in...

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Pubblicato in:Clin Cancer Res
Autori principali: Shin, Myeong-Kyun, Payne, Susan, Bilger, Andrea, Matkowskyj, Kristina A., Carchman, Evie, Meyer, Dominique S., Bentires-Alj, Mohamed, Deming, Dustin A., Lambert, Paul F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423984/
https://ncbi.nlm.nih.gov/pubmed/30530704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2843
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