Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma

PURPOSE: Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib is a selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental cancer models. Recently, we demonstra...

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I publikationen:Clin Cancer Res
Huvudupphovsmän: Song, Xinhua, Liu, Xianqiong, Wang, Haichuan, Wang, Jingxiao, Qiao, Yu, Cigliano, Antonio, Utpatel, Kirsten, Ribback, Silvia, Pilo, Maria G., Serra, Marina, Gordan, John D., Che, Li, Zhang, Shanshan, Cossu, Antonio, Porcu, Alberto, Pascale, Rosa M., Dombrowski, Frank, Hu, Hongbo, Calvisi, Diego F., Evert, Matthias, Chen, Xin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423983/
https://ncbi.nlm.nih.gov/pubmed/30084835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0284
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