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Stereoselective and Regioselective Intramolecular Friedel-Crafts Reaction of Aziridinium Ions for Synthesis of 4-Substituted Tetrahydroisoquinolines

Optically active 4-substituted tetrahydroisoquinolines were synthesized via intramolecular Friedel-Crafts (FC) reactions of aziridinium ions in a highly regioselective and stereoselective manner. Control experiments suggest the formation and ring opening of aziridinium ions as the key intermediates...

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Vydáno v:Org Lett
Hlavní autoři: Chong, Hyun-Soon, Chen, Yunwei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423956/
https://ncbi.nlm.nih.gov/pubmed/24245533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4013537
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