Chemotherapy Modulates Endocrine Therapy-Related Resistance Mutations in Metastatic Breast Cancer

PURPOSE: Accumulation of PIK3CA, ESR1, and GATA3 mutations results in resistance to endocrine therapy in breast cancer patients; however, the response of these genes to chemotherapy is unclear. Therefore, we sought to evaluate the genetic response of circulating tumor DNA (ctDNA) to chemotherapy in...

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Veröffentlicht in:Transl Oncol
Hauptverfasser: Zhou, Dabo, Ouyang, Quchang, Liu, Liping, Liu, Jingyu, Tang, Yu, Xiao, Mengjia, Wang, Yikai, He, Qiongzhi, Hu, Zhe-Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2019
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423490/
https://ncbi.nlm.nih.gov/pubmed/30893632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.02.014
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