PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies

Nearly half of metastatic breast cancers (MBC) have genetic aberrations in the PI3K/AKT pathway. To investigate the distinct effect of these aberrations on MBC, 193 MBC patients who progressed after the early line (≤2) salvage treatment voluntarily received next generation sequencing (NGS) for a pan...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Tang, Yu, Li, Jing, Xie, Ning, Yang, Xiaohong, Liu, Liping, Wu, Hui, Tian, Can, He, Ying, Wang, Xiao, He, Qiongzhi, Hu, Zhe-Yu, Ouyang, Quchang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053638/
https://ncbi.nlm.nih.gov/pubmed/31980592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102701
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