Germline PALB2 Mutations in Cancers and Its Distinction From Somatic PALB2 Mutations in Breast Cancers

PALB2 is an important BRCAx candidate for familial breast cancers (FBC). PALB2 pathogenic variants (PVs) may not to conform to “two hit” paradigm. However, a recent study demonstrates that in the majority PALB2 germline mutant breast cancers, the loss of heterozygosity (LOH) and somatic point mutati...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Hu, Zhe-Yu, Liu, Liping, Xie, Ning, Lu, Jun, Liu, Zhentian, Tang, Yu, Wang, Yikai, Yang, Jianbo, Ouyang, Quchang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482549/
https://ncbi.nlm.nih.gov/pubmed/33193564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00829
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