Germline PALB2 Mutations in Cancers and Its Distinction From Somatic PALB2 Mutations in Breast Cancers

PALB2 is an important BRCAx candidate for familial breast cancers (FBC). PALB2 pathogenic variants (PVs) may not to conform to “two hit” paradigm. However, a recent study demonstrates that in the majority PALB2 germline mutant breast cancers, the loss of heterozygosity (LOH) and somatic point mutati...

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Udgivet i:Front Genet
Main Authors: Hu, Zhe-Yu, Liu, Liping, Xie, Ning, Lu, Jun, Liu, Zhentian, Tang, Yu, Wang, Yikai, Yang, Jianbo, Ouyang, Quchang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482549/
https://ncbi.nlm.nih.gov/pubmed/33193564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00829
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