Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators

Sirtuin-1 (SirT1) catalyzes NAD(+)-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. Activation of SirT1 mitigates metabolic perturbations associated with diabetes and obesity. Pharmacologic molecul...

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Udgivet i:Redox Biol
Main Authors: Shao, Di, Yao, Chunxiang, Kim, Maya H., Fry, Jessica, Cohen, Richard A., Costello, Catherine E., Matsui, Reiko, Seta, Francesca, McComb, Mark E., Bachschmid, Markus M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423473/
https://ncbi.nlm.nih.gov/pubmed/30877853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101150
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