A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress

Sirtuin-1 (SirT1), a member of the NAD(+)-dependent class III histone deacetylase family, is inactivated in vitro by oxidation of critical cysteine thiols. In a model of metabolic syndrome, SirT1 activation attenuated apoptosis of hepatocytes and improved liver function including lipid metabolism. W...

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Autors principals: Shao, Di, Fry, Jessica L., Han, Jingyan, Hou, Xiuyun, Pimentel, David R., Matsui, Reiko, Cohen, Richard A., Bachschmid, Markus M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953247/
https://ncbi.nlm.nih.gov/pubmed/24451382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520403
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