[Ru(bpy)(2)(NO)SO(3)](PF(6)), a Nitric Oxide Donating Ruthenium Complex, Reduces Gout Arthritis in Mice

Monosodium urate crystals (MSU) deposition induces articular inflammation known as gout. This disease is characterized by intense articular inflammation and pain by mechanisms involving the activation of the transcription factor NFκB and inflammasome resulting in the production of cytokines and oxid...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Rossaneis, Ana C., Longhi-Balbinot, Daniela T., Bertozzi, Mariana M., Fattori, Victor, Segato-Vendrameto, Carina Z., Badaro-Garcia, Stephanie, Zaninelli, Tiago H., Staurengo-Ferrari, Larissa, Borghi, Sergio M., Carvalho, Thacyana T., Bussmann, Allan J. C., Gouveia, Florêncio S., Lopes, Luiz G. F., Casagrande, Rubia, Verri, Waldiceu A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423075/
https://ncbi.nlm.nih.gov/pubmed/30914954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00229
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