Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation

Human ileal bile acid-binding protein (hI-BABP) has a key role in the intracellular transport of bile salts. To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was investigated using NMR spectroscopy and biophy...

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Publicat a:Sci Rep
Autors principals: Horváth, Gergő, Egyed, Orsolya, Tang, Changguo, Kovács, Mihály, Micsonai, András, Kardos, József, Toke, Orsolya
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423008/
https://ncbi.nlm.nih.gov/pubmed/30886237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41180-7
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