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Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation
Human ileal bile acid-binding protein (hI-BABP) has a key role in the intracellular transport of bile salts. To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was investigated using NMR spectroscopy and biophy...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6423008/ https://ncbi.nlm.nih.gov/pubmed/30886237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41180-7 |
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