Triple threat to cancer: rationale for combining oncolytic viruses, MEK inhibitors, and immune checkpoint blockade

In a recent edition of Science Translational Medicine, we identified an enhanced therapeutic activity when talimogene laherparepvec (T-VEC) was combined with MEK inhibition in murine melanoma tumor models. MEK inhibition increased viral replication independent of mutation status. Combination therapy...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Bommareddy, Praveen K., Rabkin, Samuel D., Kaufman, Howard L.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422399/
https://ncbi.nlm.nih.gov/pubmed/30906668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1571390
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