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MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation

Melanoma is an aggressive cutaneous malignancy but advances over the past decade have resulted in multiple new therapeutic options, including molecularly targeted therapy, simmunotherapy and oncolytic virus therapy. Talimogene laherparepvec (T-VEC) is a herpes simplex-1 oncolytic virus and trametini...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Bommareddy, Praveen K., Aspromonate, Salvatore, Zloza, Andrew, Rabkin, Samuel D., Kaufman, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593827/
https://ncbi.nlm.nih.gov/pubmed/30541787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau0417
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