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MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation
Melanoma is an aggressive cutaneous malignancy but advances over the past decade have resulted in multiple new therapeutic options, including molecularly targeted therapy, simmunotherapy and oncolytic virus therapy. Talimogene laherparepvec (T-VEC) is a herpes simplex-1 oncolytic virus and trametini...
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| 出版年: | Sci Transl Med |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7593827/ https://ncbi.nlm.nih.gov/pubmed/30541787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau0417 |
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