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MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation
Melanoma is an aggressive cutaneous malignancy but advances over the past decade have resulted in multiple new therapeutic options, including molecularly targeted therapy, simmunotherapy and oncolytic virus therapy. Talimogene laherparepvec (T-VEC) is a herpes simplex-1 oncolytic virus and trametini...
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| Pubblicato in: | Sci Transl Med |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7593827/ https://ncbi.nlm.nih.gov/pubmed/30541787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau0417 |
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