Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor

Lactisole, an inhibitor of the human sweet taste receptor, has a 2-phenoxypropionic acid skeleton and has been shown to interact with the transmembrane domain of the T1R3 subunit (T1R3-TMD) of the receptor. Another inhibitor, 2,4-DP, which shares the same molecular skeleton as lactisole, was confirm...

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Udgivet i:PLoS One
Main Authors: Nakagita, Tomoya, Ishida, Akiko, Matsuya, Takumi, Kobayashi, Takuya, Narukawa, Masataka, Hirokawa, Takatsugu, Hashimoto, Makoto, Misaka, Takumi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422327/
https://ncbi.nlm.nih.gov/pubmed/30883570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213552
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