Two Distinct Determinants of Ligand Specificity in T1R1/T1R3 (the Umami Taste Receptor)

Umami taste perception in mammals is mediated by a heteromeric complex of two G-protein-coupled receptors, T1R1 and T1R3. T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to l-Glu, whereas mouse T1R1/T1R3 responds more strongly to other l-...

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Autors principals: Toda, Yasuka, Nakagita, Tomoya, Hayakawa, Takashi, Okada, Shinji, Narukawa, Masataka, Imai, Hiroo, Ishimaru, Yoshiro, Misaka, Takumi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873546/
https://ncbi.nlm.nih.gov/pubmed/24214976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494443
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