Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats

Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic fat accumulation. Moreover, fructose metaboli...

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Publicado en:J Biol Chem
Autores principales: Sanchez-Lozada, Laura G., Andres-Hernando, Ana, Garcia-Arroyo, Fernando E., Cicerchi, Christina, Li, Nanxing, Kuwabara, Masanari, Roncal-Jimenez, Carlos A., Johnson, Richard J., Lanaspa, Miguel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422088/
https://ncbi.nlm.nih.gov/pubmed/30651350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006158
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