Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats

Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic fat accumulation. Moreover, fructose metaboli...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Sanchez-Lozada, Laura G., Andres-Hernando, Ana, Garcia-Arroyo, Fernando E., Cicerchi, Christina, Li, Nanxing, Kuwabara, Masanari, Roncal-Jimenez, Carlos A., Johnson, Richard J., Lanaspa, Miguel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422088/
https://ncbi.nlm.nih.gov/pubmed/30651350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006158
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