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DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse
DNA polymerase θ (POLQ) plays an important role in alternative nonhomologous end joining or microhomology-mediated end joining (alt-NHEJ/MMEJ). Here, we show that POLQ is not only required for MMEJ to repair DNA double-strand breaks (DSBs) generated by endonucleases such as I-SceI or Cas9, but is al...
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| Pubblicato in: | J Biol Chem |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6422074/ https://ncbi.nlm.nih.gov/pubmed/30655289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005188 |
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