Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

OBJECTIVE: To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis. METHODS: CRISPR/Cas9 system directed by a multiple sgRNAs system was used in rabbit embryos to edit their LD...

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Detalhes bibliográficos
Publicado no:Lipids Health Dis
Main Authors: Yuan, Tingting, Zhong, Yi, Wang, Yingge, Zhang, Ting, Lu, Rui, Zhou, Minya, Lu, Yaoyao, Yan, Kunning, Chen, Yajie, Hu, Zhehui, Liang, Jingyan, Fan, Jianglin, Cheng, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421715/
https://ncbi.nlm.nih.gov/pubmed/30885208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-019-1013-8
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