α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY

Infection by Helicobacter pylori is the primary cause of gastric adenocarcinoma. The most potent H. pylori virulence factor is cytotoxin-associated gene A (CagA), which is translocated by a type 4 secretion system (T4SS) into gastric epithelial cells and activates oncogenic signaling pathways. The g...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sierra, Johanna C., Suarez, Giovanni, Piazuelo, M. Blanca, Luis, Paula B., Baker, Dara R., Romero-Gallo, Judith, Barry, Daniel P., Schneider, Claus, Morgan, Douglas R., Peek, Richard M., Gobert, Alain P., Wilson, Keith T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421409/
https://ncbi.nlm.nih.gov/pubmed/30804204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814497116
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