Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation

A known virulence factor of Helicobacter pylori that augments gastric cancer risk is the CagA cytotoxin. A carcinogenic derivative strain, 7.13, that has a greater ability to translocate CagA exhibits much higher hydrogenase activity than its parent noncarcinogenic strain, B128. A Δhyd mutant strain...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Wang, Ge, Romero-Gallo, Judith, Benoit, Stéphane L., Piazuelo, M. Blanca, Dominguez, Ricardo L., Morgan, Douglas R., Peek, Richard M., Maier, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992972/
https://ncbi.nlm.nih.gov/pubmed/27531909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01022-16
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