Activation of GCN2 by the ribosomal P-stalk

Cells dynamically adjust their protein translation profile to maintain homeostasis in changing environments. During nutrient stress, the kinase general control nonderepressible 2 (GCN2) phosphorylates translation initiation factor eIF2α, initiating the integrated stress response (ISR). To examine th...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Inglis, Alison J., Masson, Glenn R., Shao, Sichen, Perisic, Olga, McLaughlin, Stephen H., Hegde, Ramanujan S., Williams, Roger L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421407/
https://ncbi.nlm.nih.gov/pubmed/30804176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813352116
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