Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu(5)) have been proposed as potential therapies for various CNS disorders. These ligands bind to sites distinct from the orthosteric (or endogenous) ligand, often with improved subtype selectivity and spatio-temporal control...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Sengmany, Kathy, Hellyer, Shane D., Albold, Sabine, Wang, Taide, Jeffrey Conn, P., May, Lauren T., Christopoulos, Arthur, Leach, Katie, Gregory, Karen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420870/
https://ncbi.nlm.nih.gov/pubmed/30763654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.02.005
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