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Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu(5)) have been proposed as potential therapies for various CNS disorders. These ligands bind to sites distinct from the orthosteric (or endogenous) ligand, often with improved subtype selectivity and spatio-temporal control...
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| Vydáno v: | Neuropharmacology |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6420870/ https://ncbi.nlm.nih.gov/pubmed/30763654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.02.005 |
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