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KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
Although cortical interneurons are apparently well-placed to suppress seizures, several recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, we use an acute in vivo model of focal cortical seizures in awake behaving...
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| Publié dans: | Nat Commun |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6420604/ https://ncbi.nlm.nih.gov/pubmed/30874549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08933-4 |
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