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Histone modification signatures in human sperm distinguish clinical abnormalities

PURPOSE: Alternations to the paternal epigenome, specifically the components of sperm chromatin, can lead to infertility in humans and potentially transmit aberrant information to the embryo. One key component of sperm chromatin is the post-translational modification of histones (PTMs). We previousl...

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Publicado en:J Assist Reprod Genet
Autores principales: Schon, Samantha B., Luense, Lacey J., Wang, Xiaoshi, Bartolomei, Marisa S., Coutifaris, Christos, Garcia, Benjamin A., Berger, Shelley L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420512/
https://ncbi.nlm.nih.gov/pubmed/30397898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-018-1354-7
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