A Meningococcal Native Outer Membrane Vesicle Vaccine With Attenuated Endotoxin and Overexpressed Factor H Binding Protein Elicits Gonococcal Bactericidal Antibodies

BACKGROUND: Meningococcal outer membrane vesicle (OMV) vaccines are prepared with detergents to remove endotoxin, which also remove desirable antigens such as factor H binding protein (FHbp). Native OMV (NOMV) vaccines with genetically attenuated endotoxin do not require detergent treatment and elic...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Beernink, Peter T, Ispasanie, Emma, Lewis, Lisa A, Ram, Sanjay, Moe, Gregory R, Granoff, Dan M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420169/
https://ncbi.nlm.nih.gov/pubmed/30346576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy609
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