Implications for Gene Therapy-Limiting Expression of IL-2Rγ(c) Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance

X-linked SCID patients are deficient in functional IL-2Rγ(c) leading to the loss of IL-2/IL-4/IL-7/IL-9/IL-15/IL-21 signaling and a lack of NK and mature T cells. Patients treated with IL-2Rγ(c) gene therapy have T cells develop; however, their NK cell numbers remain low, suggesting antiviral respon...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Orr, Selinda J., Roessler, Stephen, Quigley, Laura, Chan, Tim, Ford, Jill W., O’Connor, Geraldine M., McVicar, Daniel W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417809/
https://ncbi.nlm.nih.gov/pubmed/20592278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903528
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller